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Series GSE44077 Query DataSets for GSE44077
Status Public on Mar 04, 2014
Title Gene expression profiling of the adjacent airway field cancerization in early stage NSCLC
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Previous work has shown that lung tumors and normal-appearing adjacent lung tissues share specific abnormalities that may be highly pertinent to the pathogenesis of lung cancer. However, the global and molecular adjacent airway field cancerization in non-small cell lung cancer (NSCLC) has not been characterized before.
We sought to understand the transcriptomic architecture of the adjacent airway field canerization, in conjunction with tumors, to gain additional insights into the lung cancer biology and oncogenesis.
 
Overall design We analyzed the transcriptome, using the Affymetrix Human Gene 1.0 ST platform, of matched NSCLC tumors, multiple normal airway epithelia with differential distance from the tumors as well as uninvolved normal lung tissues. We analyzed the airway field cancerization transcritpome to determine global differentially expressed cancerization profiles in adjacent airways as well as airway profiles that may be modulated by distance from tumors.
 
Contributor(s) Kadara H, Yoo S, Wistuba II
Citation(s) 24563515
Submission date Feb 05, 2013
Last update date Jul 26, 2018
Contact name Humam Kadara
Organization name University of Texas MD Anderson Cancer Center
Street address 2130 W. Holcombe Blvd
City Houston
State/province TX
ZIP/Postal code 77030
Country USA
 
Platforms (1)
GPL6244 [HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version]
Samples (226)
GSM1077844 NSCLC tissue from field cancerization case 1 [GFS_IW00307]
GSM1077845 Normal lung tissue from field cancerization case 1 [GFS_IW00308]
GSM1077846 NSCLC tissue from field cancerization case 1 [GFS_IW00309]
Relations
BioProject PRJNA188511

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE44077_RAW.tar 986.1 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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