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Status |
Public on May 13, 2013 |
Title |
GR and Klf15 regulate gene expression dynamics and integrate signals through feed forward circuitry |
Organism |
Mus musculus |
Experiment type |
Expression profiling by array
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Summary |
The glucocorticoid receptor (GR) regulates adaptive transcriptional programs that alter metabolism in response to stress. Network properties that allow GR to tune gene expression to match specific physiologic demands are poorly understood. We analyzed the transcriptional consequences of GR activation in murine lungs deficient for Klf15, a transcriptional regulator of amino acid metabolism that is induced by glucocorticoids and fasting
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Overall design |
Wild type and Klf15 KO mice were treated with dexamethsone or saline control for 4 and 8 hours.
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Contributor(s) |
Gerber AN, Sasse SK, Mailloux CM, Wang Q, Barczak AJ |
Citation(s) |
23508109 |
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Submission date |
Feb 26, 2013 |
Last update date |
Jan 12, 2017 |
Contact name |
Andrea J Barczak |
Organization name |
UCSF Sandler Center Functional Genomics Core Facility
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Street address |
1550 4th St Rock Hall 545
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City |
San Francisco |
State/province |
CA |
ZIP/Postal code |
94143 |
Country |
USA |
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Platforms (1) |
GPL7202 |
Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version) |
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Samples (29)
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Relations |
BioProject |
PRJNA191037 |