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Series GSE45050 Query DataSets for GSE45050
Status Public on Aug 25, 2017
Title Expression data from human hepatocellular carcinoma (HCC), Cirrhosis, and non-tumor liver tissues.
Organism Homo sapiens
Experiment type Expression profiling by array
Summary There are significant differences in the expression of genes that regulate metabolic pathways in HCC as compared to Cirrhosis or non-tumor liver tissues. These charcteristic pathways can be exploited for metabolic imaging biomarkers of HCC.
We used microarrays to perform genome-wide association study expression in human Grade III hepatocellular carcinoma and surrounding tissues.
Overall design Human tissues were obtained from as matched paired (HCC vs Cirrhosis or HCC vs non-tumor) or individually, and total RNA was exracted from these tissues. Quality control was performed on the total RNA to assess the quality and integrity of the sample. Affymetrix genechip for microarray gene analysis in two separate experiment. Statistical comparisons were made between groups and between paired samples of the same patient.
Contributor(s) Darpolor MM, Kaplan DE
Citation(s) 24497316
Submission date Mar 12, 2013
Last update date Jul 26, 2018
Contact name Moses Morakortoi Darpolor
Phone 2158981805
Organization name University of Pennsylvania
Department Radiology
Street address 423 Guardian Drive
City Philadelphia
State/province PA
ZIP/Postal code 19104
Country USA
Platforms (1)
GPL6244 [HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version]
Samples (16)
GSM1096614 Cirrhosis of liver CR561125
GSM1096615 hepatocellular carcinoma CR560983
GSM1096616 non-tumor liver CR562704
BioProject PRJNA192897

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SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE45050_RAW.tar 68.2 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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