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| Status |
Public on Feb 01, 2021 |
| Title |
Integrated microRNA and mRNA Signatures Associated with Survival in Triple Negative Breast Cancer II |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
Non-coding RNA profiling by array
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| Summary |
Triple negative breast cancer (TNBC) includes basal and non-basal subclasses. To further stratify TNBC we determined microRNA (miRNA) and mRNA expression profiles, linked specific miRNA signatures to patient survival and used miRNA/mRNA anti-correlations to identify TNBC subclasses associated with expression of canonical signal pathways
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| Overall design |
RNA was isolated from formalin-fixed paraffin-embedded tissue cores of 165 primary tumors, 59 adjacent normal and 54 lymph node metastatic samples and expression of 664 miRNAs and 230 cancer-associated mRNAs was assessed for each sample using the nanoString nCounter platform. Kaplan-Meier distant-disease free and overall survival curves were compared using the log-rank test. Cox proportional hazard regression and risk score analysis were used to identify miRNAs for classification of patients with significantly different prognoses.
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| Contributor(s) |
Cascione L, Gasparini P |
| Citation(s) |
23405235 |
| |
| Submission date |
Mar 26, 2013 |
| Last update date |
Feb 17, 2021 |
| Contact name |
Luciano Cascione |
| E-mail(s) |
luciano.cascione@ior.usi.ch
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| Organization name |
IOR
|
| Department |
Lymphoma & Genomics Research Program
|
| Street address |
Via Chiesa 5
|
| City |
Bellinzona |
| State/province |
Ticino |
| ZIP/Postal code |
6500 |
| Country |
Switzerland |
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| Platforms (2) |
| GPL16231 |
Nanostring nCounter Human microRNA Expression Platform |
| GPL16299 |
NanoString nCounter mRNA Human Cancer Reference Kit |
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| Samples (536)
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| Relations |
| BioProject |
PRJNA198199 |
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