|
Status |
Public on Feb 01, 2021 |
Title |
Integrated microRNA and mRNA Signatures Associated with Survival in Triple Negative Breast Cancer II |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by array Non-coding RNA profiling by array
|
Summary |
Triple negative breast cancer (TNBC) includes basal and non-basal subclasses. To further stratify TNBC we determined microRNA (miRNA) and mRNA expression profiles, linked specific miRNA signatures to patient survival and used miRNA/mRNA anti-correlations to identify TNBC subclasses associated with expression of canonical signal pathways
|
|
|
Overall design |
RNA was isolated from formalin-fixed paraffin-embedded tissue cores of 165 primary tumors, 59 adjacent normal and 54 lymph node metastatic samples and expression of 664 miRNAs and 230 cancer-associated mRNAs was assessed for each sample using the nanoString nCounter platform. Kaplan-Meier distant-disease free and overall survival curves were compared using the log-rank test. Cox proportional hazard regression and risk score analysis were used to identify miRNAs for classification of patients with significantly different prognoses.
|
|
|
Contributor(s) |
Cascione L, Gasparini P |
Citation(s) |
23405235 |
|
Submission date |
Mar 26, 2013 |
Last update date |
Feb 17, 2021 |
Contact name |
Luciano Cascione |
E-mail(s) |
luciano.cascione@ior.usi.ch
|
Organization name |
IOR
|
Department |
Lymphoma & Genomics Research Program
|
Street address |
Via Chiesa 5
|
City |
Bellinzona |
State/province |
Ticino |
ZIP/Postal code |
6500 |
Country |
Switzerland |
|
|
Platforms (2) |
GPL16231 |
Nanostring nCounter Human microRNA Expression Platform |
GPL16299 |
NanoString nCounter mRNA Human Cancer Reference Kit |
|
Samples (536)
|
|
Relations |
BioProject |
PRJNA198199 |