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| Status |
Public on Aug 18, 2013 |
| Title |
Addiction of t(8;21) and inv(16) AML to native RUNX1 [ChIP-Seq data] |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
Cancer cells maintain a sensitive balance between growth-promoting oncogenes and apoptosis inhibitors. We show that WT RUNX1 is required for survival of t(8;21)-Kasumi-1 and inv(16)-ME-1 AML cell lines. The malignant AML phenotype is sustained by a delicate AML1-ETO/RUNX1 balance that involves competition for common DNA binding sites regulating a subset of AML1-ETO/RUNX1 targets.
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| Overall design |
Genomewide sequencing data is included herein: Transcription factors RUNX1 c-terminus and n-terminus which is shared with AML1-ETO were profiled independently), AML1-ETO and AP4 were profiled using ChIP-Seq in Kasumi-1 cells, as well as control ChIP-Seq experiments of non immune serum. Two replicates were performed for each transcription factor profiling and control experiment.
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| Contributor(s) |
Ben Ami O, Friedman D |
| Citation(s) |
24055056 |
| |
| Submission date |
Apr 03, 2013 |
| Last update date |
May 15, 2019 |
| Contact name |
Yoram Groner |
| E-mail(s) |
yoram.groner@weizmann.ac.il
|
| Organization name |
Weizmann institute
|
| Department |
Molecular Genetics
|
| Street address |
234 Herzl St.
|
| City |
Rehovot |
| ZIP/Postal code |
76100 |
| Country |
Israel |
| |
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| Platforms (1) |
| GPL10999 |
Illumina Genome Analyzer IIx (Homo sapiens) |
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| Samples (12)
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| This SubSeries is part of SuperSeries: |
| GSE45748 |
Addiction of t(8;21) and inv(16) AML to native RUNX1 |
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| Relations |
| BioProject |
PRJNA196162 |
| SRA |
SRP020494 |
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