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Status |
Public on May 06, 2013 |
Title |
Identification of differentially expressed transcripts and pathways one week and six months following implant of left ventricular devices |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by high throughput sequencing
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Summary |
A specific set of genes involved in regulating cellular immune response, antigen presentation, and T cell activation and survival were down-regulated 7 days after LVAD placement. 6 months following LVAD placement, the expression levels of these genes were significantly increased; yet importantly, remained significantly lower than age and sex-matched samples from healthy controls.
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Overall design |
Examination of the effect of LVAD implant on peripheral blood transcriptome. Blood was drawn before LVAD placement, 7 days post implant, and 180 days post implant. RNA sequencing was performaed on all samples.
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Contributor(s) |
Mitchell A, Hall JL |
Citation(s) |
- Mitchell A, Guan W, Staggs R, Hamel A et al. Identification of differentially expressed transcripts and pathways in blood one week and six months following implant of left ventricular assist devices. PLoS One 2013;8(10):e77951. PMID: 24205042
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Submission date |
May 06, 2013 |
Last update date |
May 15, 2019 |
Contact name |
Rod A. Staggs |
E-mail(s) |
stagg004@umn.edu
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Phone |
612-384-6451
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Organization name |
Minnesota Informatics
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Street address |
20040 Cottagewood Ave
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City |
Excelsior |
State/province |
MN |
ZIP/Postal code |
55331 |
Country |
USA |
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Platforms (1) |
GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
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Samples (25)
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Relations |
BioProject |
PRJNA201433 |
SRA |
SRP022133 |