|
| Status |
Public on Oct 28, 2013 |
| Title |
Gene expression profiles of EZH2 knockdown |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Enhancer of Zeste Homolog 2 (EZH2) is a histone methyltransferase that catalyzes the trimethylation of histone H3 lysine 27 (H3K27me3). EZH2 expression is significantly upregulated in MPNST. In our study, we investigated the function of EZH2 and the molecular mechanisms that are regulated by EZH2 in MPNST pathogenesis. Our findings enhance the knowledge of EZH2’s function and biology, and have the potential to provide a novel therapeutic approach for MPNST patients in the clinic.
|
| |
|
| Overall design |
An EZH2 knockdown experiment was carried out in MPNST cells. There are one control and one siEZH2 samples for two cell lines (724 and 462) and two repeats for each cell line, so in total there are 8 samples.
Two group comparison
|
| |
|
| Contributor(s) |
Lev D, Creighton C, Zhang Y, Zhang P |
| Citation(s) |
24132643 |
| |
| Submission date |
May 14, 2013 |
| Last update date |
Jan 28, 2016 |
| Contact name |
Chad Creighton |
| E-mail(s) |
creighto@bcm.tmc.edu
|
| Organization name |
Baylor College of Medicine
|
| Department |
Biostatistics, Ducan Cancer Center
|
| Street address |
One Baylor Plaza, Mail Stop: BCM305
|
| City |
Houston |
| State/province |
TX |
| ZIP/Postal code |
77030 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL10904 |
Illumina HumanHT-12 V4.0 expression beadchip (gene symbol) |
|
| Samples (8)
|
|
| This SubSeries is part of SuperSeries: |
| GSE47477 |
Gene expression and microRNA profiles of EZH2 knockdown |
|
| Relations |
| BioProject |
PRJNA202988 |
Less...
More...