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Status |
Public on Feb 03, 2015 |
Title |
Genome-wide map of GATA6 DNA binding in human PDAC cells |
Organism |
Homo sapiens |
Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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Summary |
By studying a mouse model, as well as human tumors samples and cell lines, we have revealed a tumor suppressive role for Gata6 in the pathogenesis of pancreatic ductal adenocarcinoma (PDAC). In order to understand the mechanism underlying such tumor suppressive function, we analyzed the genome-wide DNA-binding of GATA6 in a human PDAC cell line (PaTu8988S). GATA6 is found to bind the promoter of genes involved in the epithelial differentiation programme, as well as of genes involved in the mesenchymal programme. With this we describe a novel GATA6-dependent mechanism of regulation of EMT.
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Overall design |
Examination of GATA6 binding to the DNA in a human PDAC cell line
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Contributor(s) |
Martinelli P, Carrillo de Santa Pau E, Real FX |
Citation(s) |
- Martinelli P, Madriles F, Cañamero M, Pau EC et al. The acinar regulator Gata6 suppresses KrasG12V-driven pancreatic tumorigenesis in mice. Gut 2016 Mar;65(3):476-86. PMID: 25596178
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Submission date |
May 30, 2013 |
Last update date |
May 15, 2019 |
Contact name |
Enrique Carrillo de Santa Pau |
E-mail(s) |
enrique.carrillo@imdea.org
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Organization name |
Spanish National Cancer Research Centre (CNIO)
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Department |
Cancer Cell Biology Programme
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Lab |
Epithelial Carcinogenesis group
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Street address |
C/ Melchor Fernández Almagro, 3
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City |
Madrid |
ZIP/Postal code |
28029 |
Country |
Spain |
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Platforms (1) |
GPL10999 |
Illumina Genome Analyzer IIx (Homo sapiens) |
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Samples (2) |
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This SubSeries is part of SuperSeries: |
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Relations |
BioProject |
PRJNA205985 |
SRA |
SRP023467 |