|
| Status |
Public on May 31, 2016 |
| Title |
Genome-wide analysis of parental and wild-type SK-N-Be(2)C neuroblastoma cell lines as well as those co-treated with the histone deacetylase inhibitor SAHA |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Analysis of varied biologic pathways in neuroblastoma SK-N-Be(2)C cells grown in doxorubicin and/or SAHA. We hypothesized that SK-N-Be(2)C cells undergo a mesenchymal change through mesenchymal change resulting in a more invasive as well as drug resistant phenotype, and that the mechanism of SAHAs effect on drug resistance may be revealed through this analysis.
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| |
|
| Overall design |
Total RNA was isolated from wild type, SAHA treated wild type cells, doxorubicin resistant, and SAHA treated doxorubicin resistant SK-N-Be(2)C cell lines in triplicate.
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| |
|
| Contributor(s) |
Naiditch J, Jie C |
| Citation(s) |
22829886 |
| |
| Submission date |
Jun 05, 2013 |
| Last update date |
Jul 18, 2024 |
| Contact name |
Chunfa Jie |
| E-mail(s) |
cjie.jhmi@gmail.com
|
| Phone |
3124043831
|
| Organization name |
Des Moines University
|
| Street address |
3200 Grand Ave
|
| City |
Des Moines |
| State/province |
IA |
| ZIP/Postal code |
50266 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL10558 |
Illumina HumanHT-12 V4.0 expression beadchip |
|
| Samples (12)
|
| GSM1154300 |
SK-N-Be(2)C-wild type treated with SAHA 1 |
| GSM1154301 |
SK-N-Be(2)C-wild type treated with SAHA 2 |
| GSM1154302 |
SK-N-Be(2)C-wild type treated with SAHA 3 |
| GSM1154303 |
SK-N-Be(2)C-doxorubicin resistant 1 |
| GSM1154304 |
SK-N-Be(2)C-doxorubicin resistant 2 |
| GSM1154305 |
SK-N-Be(2)C-doxorubicin resistant 3 |
| GSM1154306 |
SK-N-Be(2)C-doxorubicin resistant + treated with SAHA 1 |
| GSM1154307 |
SK-N-Be(2)C-doxorubicin resistant + treated with SAHA 2 |
| GSM1154308 |
SK-N-Be(2)C-doxorubicin resistant + treated with SAHA 3 |
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| This SubSeries is part of SuperSeries: |
| GSE47670 |
Microarray analysis of derived doxorubicin resistant neuroblastoma SK-N-Be(2)C and SK-N-SH cell lines |
|
| Relations |
| BioProject |
PRJNA207086 |
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