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Series GSE47986 Query DataSets for GSE47986
Status Public on Dec 31, 2013
Title Evidence for the independent evolution of "functional progesterone withdrawal" in primates and guinea pigs: a comparative transcriptomic study
Organism Cavia porcellus
Experiment type Expression profiling by high throughput sequencing
Summary Cervix remodeling (CRM) is a critical process in preparation for parturition. Early cervix shortening is a powerful clinical predictor of preterm birth, and thus understanding how CRM is regulated is important for the prevention of prematurity. Humans and other primates differ from most other mammals by the maintenance of high levels of systemic progesterone concentrations and thus differ dramatically from most model species. Humans have been hypothesized to perform functional progesterone withdrawal (FPW), but the mechanisms of FPW are not known. Guinea pigs are similar to humans as they also maintain high progesterone concentrations through parturition. The aim of this study is to document gene expression during pregnancy in the guinea pig uterine cervix in order to assess whether guinea pig can be used as a model for human FPW
Overall design Total RNA obtained from isolated cervical tissues from non-pregnant and two genstation stages (mid-term, and late-term but not in labor).
Contributor(s) Nnamani MC, Romero R, Wagner GP, Plaza S
Citation(s) 24481205
Submission date Jun 14, 2013
Last update date May 15, 2019
Contact name Mauris Chukwudebelu Nnamani
Organization name Yale University
Department Systems Biology institute, EEB
Lab Gunter Wagner
Street address 300 heffernan drive B31-ABC/rm269
City west Haven
State/province CT
ZIP/Postal code 06512
Country USA
Platforms (1)
GPL17296 Illumina HiSeq 2000 (Cavia porcellus)
Samples (10)
GSM1164130 Non-pregnant cervix tissue rep1
GSM1164131 Non-pregnant cervix tissue rep2
GSM1164132 Non-pregnant cervix tissue rep3
BioProject PRJNA208534
SRA SRP026067

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Supplementary file Size Download File type/resource
GSE47986_matrix_normalized_data.txt.gz 1.4 Mb (ftp)(http) TXT
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