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| Status |
Public on Jun 23, 2016 |
| Title |
Gene expression changes in response to carmustine treatment in glioma cells with acquired carmustine resistance versus parent cell lines |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Three glioma cell lines (A172CR, SW1088CR, and U87CR) developed resistance to carmustine by prolonged sublethal exposure to 11 cycles of increasing carmustine exposure. The gene expression of parent versus resistant cell lines was compared upon exposure to carmustine. DMSO (vehicle) treatment was used as a control.
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| Overall design |
After 1 hour of exposure to either carmustine or DMSO, the gene expression profile of resistant versus parent cell lines was quantified. Indirect pairwise comparison between resistant versus parent cell line upon exposure to either carmustine or DMSO was performed in pair of dye swap experiments.
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| Contributor(s) |
Hamed SS, Roth CM |
| Citation missing |
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| Submission date |
Jul 01, 2013 |
| Last update date |
Jun 23, 2016 |
| Contact name |
Salaheldin Sobhi Hamed |
| E-mail(s) |
salaheldinh@gmail.com
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| Phone |
(301)796-0116
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| Organization name |
U.S. FDA
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| Department |
CDER/OTR
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| Lab |
DDSR
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| Street address |
10903 New Hampshire Ave
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| City |
Silver Spring |
| State/province |
Maryland |
| ZIP/Postal code |
20993 |
| Country |
USA |
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| Platforms (1) |
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| Samples (24)
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| GSM1179181 |
A172 exposure to Carmustine and DMSO, rep1 |
| GSM1179182 |
A172 exposure to Carmustine and DMSO, rep2 |
| GSM1179183 |
A172 exposure to Carmustine and DMSO, rep3 |
| GSM1179184 |
A172 exposure to Carmustine and DMSO, rep4 |
| GSM1179185 |
A172CR exposure to Carmustine and DMSO, rep1 |
| GSM1179186 |
A172CR exposure to Carmustine and DMSO, rep2 |
| GSM1179187 |
A172CR exposure to Carmustine and DMSO, rep3 |
| GSM1179188 |
A172CR exposure to Carmustine and DMSO, rep4 |
| GSM1179191 |
SW1088 exposure to Carmustine and DMSO, rep1 |
| GSM1179192 |
SW1088 exposure to Carmustine and DMSO, rep2 |
| GSM1179193 |
SW1088 exposure to Carmustine and DMSO, rep3 |
| GSM1179194 |
SW1088 exposure to Carmustine and DMSO, rep4 |
| GSM1179195 |
SW1088CR exposure to Carmustine and DMSO, rep1 |
| GSM1179196 |
SW1088CR exposure to Carmustine and DMSO, rep2 |
| GSM1179197 |
SW1088CR exposure to Carmustine and DMSO, rep3 |
| GSM1179198 |
SW1088CR exposure to Carmustine and DMSO, rep4 |
| GSM1179199 |
U87 exposure to Carmustine and DMSO, rep1 |
| GSM1179200 |
U87 exposure to Carmustine and DMSO, rep2 |
| GSM1179201 |
U87 exposure to Carmustine and DMSO, rep3 |
| GSM1179202 |
U87 exposure to Carmustine and DMSO, rep4 |
| GSM1179203 |
U87CR exposure to Carmustine and DMSO, rep1 |
| GSM1179204 |
U87CR exposure to Carmustine and DMSO, rep2 |
| GSM1179205 |
U87CR exposure to Carmustine and DMSO, rep3 |
| GSM1179206 |
U87CR exposure to Carmustine and DMSO, rep4 |
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| Relations |
| BioProject |
PRJNA210212 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE48458_RAW.tar |
49.7 Mb |
(http)(custom) |
TAR (of GPR) |
| Processed data included within Sample table |
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