|
| Status |
Public on Sep 30, 2013 |
| Title |
Expression data from responders/nonresponders before/after receiving DLI for relapse of CML s/p BMT |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Increasing evidence across malignancies suggests that infiltrating T cells at the site of disease are crucial to tumor control. We hypothesized that marrow-infiltrating immune populations play a critical role in response to donor lymphocyte infusion (DLI), an established and potentially curative immune therapy whose precise mechanism remains unknown. We therefore analyzed marrow-infiltrating immune populations in 29 patients (22 responders, 7 nonresponders) with relapsed chronic myelogenous leukemia who received CD4+ DLI in the pre-tyrosine kinase inhibitor era.
We used microarrays to detail the global programme of gene expression underlying T cell infiltration into bone marrow of responders and nonresponders to DLI.
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|
| Overall design |
mRNA expression profiling of marrow-infiltrating CD3+ positively selected T cells of 4 responders compared to 2 non-responders, before and after DLI, was performed on Affymetrix microarrays.
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| Contributor(s) |
Bachireddy P, Hainz U, Rooney M, Hacohen N, Wu CJ |
| Citation(s) |
24357730 |
| |
| Submission date |
Jul 21, 2013 |
| Last update date |
Dec 06, 2018 |
| Contact name |
Pavan Bachireddy |
| E-mail(s) |
pavan_bachireddy@dfci.harvard.edu
|
| Organization name |
Dana-Farber Cancer Institute
|
| Lab |
Catherine Wu, MD
|
| Street address |
77 Avenue Louis Pasteur
|
| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02115 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL571 |
[HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array |
|
| Samples (12)
|
| GSM1193265 |
marrow CD3 T cells_post_R2 (responder) |
| GSM1193266 |
marrow CD3 T cells_pre_R3 (responder) |
| GSM1193267 |
marrow CD3 T cells_post_R3 (responder) |
| GSM1193268 |
marrow CD3 T cells_pre_R4 (responder) |
| GSM1193269 |
marrow CD3 T cells_post_R4 (responder) |
| GSM1193270 |
marrow CD3 T cells_pre_NR1 (nonresponder) |
| GSM1193271 |
marrow CD3 T cells_post_NR1 (nonresponder) |
| GSM1193272 |
marrow CD3 T cells_pre_NR2 (nonresponder) |
| GSM1193273 |
marrow CD3 T cells_post_NR2 (nonresponder) |
|
| Relations |
| BioProject |
PRJNA212860 |
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