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| Status |
Public on Jul 10, 2019 |
| Title |
Gene Expresion in Ausitm Spectrum Disorders (ASD) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
We postulated that specific differences in alternative splicing/exon usage in immune blood cells may be present in ASD boys, and this might differ in ASD boys with large total cerebral volumes (ASD_LTCV) versus ASD boys with normal total cerebral volumes (ASD_NTCV). Thus, we compared ASD and ASD sub-groups related to total cerebral volume to typically developing (TD) controls.
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| Overall design |
Blood from young boys with ASD and TD was collected, and the extracted RNA was interrogated on Affymetrix GeneChip ® Human Exon 1.0 ST arrays. In adition, Total Cerebral Volume (TCV), measured by MRI was considered as a subphenotype. 30 boys with ASD (20 with normal TCV and 10 with large TCV) and 20 matched typically developing controls were assayed.
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| Contributor(s) |
Stamova BB, Tian Y, Nordahl CW, Shen MD, Rogers S, Amaral DG, Sharp FR |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Jul 22, 2013 |
| Last update date |
Jul 11, 2019 |
| Contact name |
Boryana Stamova |
| E-mail(s) |
boryana.stamova@ucdmc.ucdavis.edu
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| Phone |
916-703-0384
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| Organization name |
University of California, Davis Medical Center
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| Department |
Neurology; MIND Institute
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| Lab |
Dr. Frank Sharp
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| Street address |
2805 50th Street
|
| City |
Sacramento |
| State/province |
California |
| ZIP/Postal code |
95817 |
| Country |
USA |
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| Platforms (1) |
| GPL5188 |
[HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [probe set (exon) version] |
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| Samples (50)
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| Relations |
| BioProject |
PRJNA213003 |
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