|
| Status |
Public on Sep 01, 2013 |
| Title |
Specific extracellular matrix remodeling signature of colon hepatic metastases [HG-U133A] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
To identify genes implicated in metastatic colonization of the liver in colorectal cancer, we collected pairs of primary tumors and hepatic metastases before chemotherapy in 13 patients. We compared mRNA expression in the pairs of patients to identify genes deregulated during metastatic evolution. We then validated the identified genes using data obtained by different groups. The 33-gene signature was able to classify 87% of hepatic metastases, 98% of primary tumors, 97% of normal colon mucosa, and 95% of normal liver tissues in six datasets obtained using five different microarray platforms. The identified genes are specific to colon cancer and hepatic metastases since other metastatic locations and hepatic metastases originating from breast cancer were not classified by the signature. Gene Ontology term analysis showed that 50% of the genes are implicated in extracellular matrix remodeling, and more precisely in cell adhesion, extracellular matrix organization and angiogenesis. Because of the high efficiency of the signature to classify colon hepatic metastases, the identified genes represent promising targets to develop new therapies that will specifically affect hepatic metastasis microenvironment.
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| |
|
| Overall design |
57 samples of patients with stage IV colorectal cancer. We compared using Affymetrix chips gene expression profiles between primary tumors and hepatic metastases
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| |
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| Contributor(s) |
Del Rio M, Mollevi C, Martineau P |
| Citation(s) |
24023955, 17327601 |
| |
| Submission date |
Jul 30, 2013 |
| Last update date |
Aug 10, 2018 |
| Contact name |
Pierre Martineau |
| E-mail(s) |
pierre.martineau@inserm.fr
|
| Phone |
+33 4 67 61 37 43
|
| Organization name |
Inserm
|
| Department |
IRCM
|
| Street address |
208 Rue des Apothicaires
|
| City |
Montpellier Cedex 5 |
| ZIP/Postal code |
34298 |
| Country |
France |
| |
|
| Platforms (1) |
| GPL96 |
[HG-U133A] Affymetrix Human Genome U133A Array |
|
| Samples (57)
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| This SubSeries is part of SuperSeries: |
| GSE62322 |
Gene expression signature in advanced colorectal cancer patients select drugs and response for the use of leucovorin, fluorouracil, and irinotecan |
|
| Relations |
| BioProject |
PRJNA213714 |
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