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| Status |
Public on Aug 03, 2013 |
| Title |
Epigenetic regulation of sex determination by the histone demethylase Jmjd1a |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Developmental gene expression is defined through cross-talk between the function of transcription factors and epigenetic status including histone modification. Although several known transcription factors play crucial roles in mammalian sex determination, how chromatin regulation contributes to this process is unknown. We observed male-to-female sex reversal in mice lacking the H3K9 demethylase Jmjd1a, and found that Jmjd1a directly regulates expression of the mammalian Y chromosome sex-determining gene Sry, by regulating H3K9me2 marks. These studies reveal a pivotal role for epigenetic regulation in mammalian sex determination, and provide new impetus for identifying additional causes of disorders of sex determination by environmental factors.
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| Overall design |
Gene expression patterns were measured in gonadal somatic cells of Jmjd1a mutant and control embryos at E11.5. Three biological replicates were performed in each group.
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| Contributor(s) |
Kuroki S, Matoba S, Akiyoshi M, Matsumura Y, Miyachi H, Mise N, Abe K, Ogura A, Wilhelm D, Koopman P, Nozaki M, Kanai Y, Shinkai Y, Tachibana M |
| Citation(s) |
24009392 |
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| Submission date |
Aug 02, 2013 |
| Last update date |
Jan 12, 2017 |
| Contact name |
Shogo Matoba |
| E-mail(s) |
shogomatoba@gmail.com
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| Organization name |
RIKEN BioResource Research Center
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| Street address |
3-1-1, Koyadai
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| City |
Tsukuba |
| State/province |
Ibaraki |
| ZIP/Postal code |
305-0074 |
| Country |
Japan |
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| Platforms (1) |
| GPL7202 |
Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA214090 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE49513_RAW.tar |
25.8 Mb |
(http)(custom) |
TAR (of TXT) |
| GSE49513_processed_data_FC2.xlsx.gz |
140.3 Kb |
(ftp)(http) |
XLSX |
| Processed data included within Sample table |
| Processed data are available on Series record |
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