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Series GSE507 Query DataSets for GSE507
Status Public on Jul 16, 2003
Title Novel estrogen and tamoxifen induced genes
Organism Homo sapiens
Experiment type Expression profiling by SAGE
Summary The breast cancer promoting effects of estrogen and the chemopreventive effects of tamoxifen are thought to be mediated by the estrogen receptor, a ligand-dependent transcription factor. Therefore, comprehensive analysis of gene expression profiles following estrogen or tamoxifen treatment may help us better understand the role estrogen plays in tumorigenesis. We utilized SAGE (Serial Analysis of Gene Expression) technology to identify genes regulated by estrogen and tamoxifen in the ZR75-1 estrogen dependent breast cancer cell line. In this manner we have identified several genes that were regulated by estrogen or tamoxifen. Here we report the identification and initial characterization of EIT-6 (Estrogen Induced Tag-6), a novel nuclear protein and a new member of the evolutionarily conserved SM-20 family of growth regulatory immediate-early genes. EIT-6 appears to be a direct transcriptional target of the estrogen receptor and constitutive expression of EIT-6 promotes colony growth in human breast cancer cells. These data indicate that EIT-6 may play a role in estrogen induced cell growth.
Keywords: other
Contributor(s) Seth P, Krop I, Porter D, Polyak K
Citation(s) 11850811
Submission date Jul 02, 2003
Last update date Apr 18, 2012
Contact name Kornelia Polyak
Phone 617-632-2106
Organization name Dana-Farber Cancer Institute
Department Medical Oncology
Lab Polyak
Street address 450 Brookline Ave
City Boston
State/province MA
ZIP/Postal code 02215
Country USA
Platforms (1)
GPL4 SAGE:10:NlaIII:Homo sapiens
Samples (3)
GSM1128 ZR75-1 untreated
GSM1129 ZR75-1 estrogen treated
GSM1130 ZR75-1 tamoxifen
BioProject PRJNA85225

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