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| Status |
Public on Jun 05, 2015 |
| Title |
Expression data from mouse perigonadal white adipose tissue - various mutant conditions [gene-level analysis] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Progerin-expressing mice (HGPS-like) demonstrated increased energy metabolism and lipodystrophy. Increased mitochondrial biogenesis was found in adipose tissue from HGPS-like mice, whereas lamin C-only mice had fewer mitochondria. Thus we analyse which molecular pathways mediated the changes in adipose tissue caused by lamin C and progerin expression and the roles of these pathways in energy metabolism and aging.
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| Overall design |
10 cDNAs samples were analysed. We compared the mean fold change of 2 to 4 biological replicates. We performed an unpaired Student’s t-test to compare intensities in the different biological replicates. Genes were considered significantly regulated when the fold change was ≥ 1.5, and the p-value was ≤0.05.
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| Contributor(s) |
Tazi J |
| Citation(s) |
24639560 |
| |
| Submission date |
Sep 26, 2013 |
| Last update date |
Mar 06, 2018 |
| Contact name |
Pierre de la Grange |
| E-mail(s) |
pierre.delagrange@genosplice.com
|
| Organization name |
GenoSplice technology
|
| Department |
Paris Biotech Santé
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| Street address |
29, rue du Faubourg Saint-Jacques
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| City |
Paris |
| ZIP/Postal code |
75014 |
| Country |
France |
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| Platforms (1) |
| GPL6096 |
[MoEx-1_0-st] Affymetrix Mouse Exon 1.0 ST Array [transcript (gene) version] |
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| Samples (9)
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| This SubSeries is part of SuperSeries: |
| GSE51204 |
Expression data from mouse perigonadal white adipose tissue - various mutant conditions |
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| Relations |
| BioProject |
PRJNA221586 |
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