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| Status |
Public on Jan 06, 2014 |
| Title |
Analyses of the chromatin and transcriptional basis for lateral inhibition in isolated intestinal epithelial cells. |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
We analyzed chromatin modifications, DNaseI-hypersensitive sites, and occupancy of a key secretory-lineage transcription factor, ATOH1. We found that lateral inhibition in the intestine occurs through ATOH1 exerting direct control within a broadly permissive chromatin state that is established in stem cells and is highly similar in specified progenitors of divergent potential.
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| Overall design |
Mapping chromatin modifications (H3K4me2 and H3K27ac), DNaseI hypersensitivity (DHS), and ATOH1 binding sites in isolated intestinal crypt progenitors and mature intestinal villus cells.
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| Contributor(s) |
Kim T, Li F, Ho L, Luyten A, Nalapareddy K, Long H, Verzi M, Shivdasani R |
| Citation(s) |
24413398 |
| |
| Submission date |
Oct 21, 2013 |
| Last update date |
May 15, 2019 |
| Contact name |
Fugen Li |
| E-mail(s) |
fugen_li@dfci.harvard.edu
|
| Organization name |
Dana-Farber Cancer Institute
|
| Street address |
450 Brookline Ave
|
| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02215 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL13112 |
Illumina HiSeq 2000 (Mus musculus) |
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| Samples (15)
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| This SubSeries is part of SuperSeries: |
| GSE51464 |
An epigenetic basis for lateral inhibition and lineage plasticity in intestinal differentiation |
|
| Relations |
| BioProject |
PRJNA223243 |
| SRA |
SRP031621 |
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