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| Status |
Public on Sep 14, 2018 |
| Title |
Gene expression profiling of Angioimmunoblastic T-Cell lymphoma (AITL) tumors |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Angioimmunoblastic T-Cell lymphoma (AITL) is a mature T-cell lymphoma of blood or lymph vessel immunoblasts. It is the most common subtype of T-cell lymphoma in the Western world and the second most frequent one in Asia. We sequenced nine pairs of AITL exomes and their matched normals. Frequent mutations in TET2 and RHOA were detected, and confirmed through targeted sequencing in a larger cohort of 43 samples. Gene expression profiling was performed to identify genes differentially expressed between patients with and without mutations in genes of interest.
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| Overall design |
Microarray gene expression profiling was performed on 20 AITL tumor samples. 18 were used for further study as somatic mutations were not detecting in two samples.
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| Contributor(s) |
Nairismägi M, Lim W, Lim S, Teh B |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Oct 22, 2013 |
| Last update date |
Sep 14, 2018 |
| Contact name |
Weng Khong Lim |
| E-mail(s) |
wengkhong.lim@duke-nus.edu.sg
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| Organization name |
National Cancer Centre Singapore
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| Department |
Department of Medical Sciences
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| Lab |
NCCS-VARI Translational Research Laboratory
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| Street address |
11 Hospital Drive
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| City |
Singapore |
| State/province |
Singapore |
| ZIP/Postal code |
169610 |
| Country |
Singapore |
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| Platforms (1) |
| GPL17811 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array [CDF: Brainarray HGU133Plus2_Hs_ENTREZG_v17] |
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| Samples (20)
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| Relations |
| BioProject |
PRJNA223348 |
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