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Series GSE51797 Query DataSets for GSE51797
Status Public on Oct 24, 2016
Title Hepatic expression data from 2-stage carcinogenesis study in rats
Organism Rattus norvegicus
Experiment type Expression profiling by array
Summary Hepatic gene expression profiles in 2-stage carcinogenesis study were analyzed with comprehensive DNA methylation data. Combined analysis suggested that PTEN signaling and immune response such as antigen presentation was related to one side of early heapatocarcinogenesis.
We used microarrays to obtain the global gene expression profile of livers to understand the mechanism of carcinogenesis.
 
Overall design Rat livers sampled at the timing of partial hepatectomy and terminal euthanasia were subjected to RN extraction and hybridization on Affymetrix microarrays. We sought to obtain hepatic gene expression data treated with various initiators and their succession. Briefly, each liver at 5w (partial hepatectomized sample) and 10w (terminal sample) from same animal were subjected to microarray analysis. MC (methylcellulose) and water mean vehicle of initiator and promoter, respectively. As an initiator, diethylnitrosamine (DEN), thioacetamide (TAA), methapyrilene (MP) and acetaminophen (APAP) were administered. As a promoter, phenobarbital (PB) was given in drinking water.
 
Contributor(s) Omura K, Uehara T, Morikawa Y, Hayashi H, Mitsumori K, Minami K, Kanki M, Yamada H, Ono A, Ohno Y, Urushidani T
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Submission date Oct 28, 2013
Last update date Jul 31, 2017
Contact name Ko Omura
E-mail(s) kou.omura@astellas.com
Organization name Astellas Pharma Inc.
Street address 2-1-6 Kashima yodogawa-ku
City Osaka
ZIP/Postal code 532-8514
Country Japan
 
Platforms (1)
GPL1355 [Rat230_2] Affymetrix Rat Genome 230 2.0 Array
Samples (62)
GSM1252830 5w_Rat liver MC/water_1
GSM1252831 5w_Rat liver MC/water_2
GSM1252832 5w_Rat liver MC/water_3
Relations
BioProject PRJNA225035

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE51797_RAW.tar 148.6 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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