|
| Status |
Public on Mar 31, 2014 |
| Title |
Gene regulation in human epidermal keratinocytes by a Rho kinase inhibitor (Y-27632) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
We previously demonstrated that the lifespan of primary human keratinocytes could be extended indefinitely by culture in the presence of the Rho kinase (ROCK) inhibitor Y-27632. Here, gene expression analysis of primary human epidermal keratinocytes cells grown in the presence of Y-27632 demonstrates that ROCK inhibition primarily inhibits keratinocyte differentiation.
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| |
|
| Overall design |
mRNA profiles of primary HEKs treated with and without the rho kinase inhibitor Y-27632 were generated by microarray analysis using Illumina BeadChip.
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| |
|
| Contributor(s) |
McBride AA, Jang MK |
| Citation(s) |
24774536 |
| Submission date |
Nov 19, 2013 |
| Last update date |
Aug 13, 2018 |
| Contact name |
Alison A McBride |
| E-mail(s) |
amcbride@niaid.nih.gov
|
| Phone |
3014961370
|
| Organization name |
NIAID NIH
|
| Department |
DIR
|
| Lab |
Lab of Viral Diseases
|
| Street address |
33 North Drive
|
| City |
Bethesda |
| State/province |
Maryland |
| ZIP/Postal code |
20892 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL10558 |
Illumina HumanHT-12 V4.0 expression beadchip |
|
| Samples (4)
|
| GSM1268178 |
Human epidermal keratinocyte replicate 1 |
| GSM1268179 |
Human epidermal keratinocyte replicate 2 |
| GSM1268180 |
Human epidermal keratinocyte, Y-27632 replicate 1 |
| GSM1268181 |
Human epidermal keratinocyte, Y-27632 replicate 2 |
|
| Relations |
| BioProject |
PRJNA229149 |
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