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| Status |
Public on Jan 07, 2015 |
| Title |
Geminin regulates self-renewal and fate commitment decisions in fetal hematopoietic stem cells. |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Conditional deletion of Geminin from the entire hematopoietic compartment using Vav1:iCre mice led to defective hematopoiesis/dyserythropoiesis in E15.5 mouse embryos.
The present data set includes data from lineage-negative cells isolated from homogenized livers that were dissected from E15.5.dpc embryos. The two conditions compared were wild-type versus Geminin-KO Lin- cells. The cells were collected from littermates.
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| Overall design |
Six samples were analyzed: three samples from each wild-type and Geminin-KO Lin- cells. For our analyses, we set cutoff values FC>1.5 and p-value <0.05. The analysis was carried out using the genotype criterion, but non-averaged for the three biological replicates.
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| Contributor(s) |
Taraviras S |
| Citation(s) |
25516969, 27077091 |
| |
| Submission date |
Dec 06, 2013 |
| Last update date |
Mar 04, 2019 |
| Contact name |
Stavros Taraviras |
| E-mail(s) |
taraviras@med.upatras.gr
|
| Organization name |
University of Patras
|
| Department |
School of Medicine
|
| Lab |
Stem Cell Laboratory
|
| Street address |
Asklipiou 1
|
| City |
Patras |
| State/province |
Achaia |
| ZIP/Postal code |
26504 |
| Country |
Greece |
| |
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| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (6)
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| GSM1281331 |
WT Lineage negative fetal liver cells E15.5, rep 1 |
| GSM1281332 |
WT Lineage negative fetal liver cells E15.5, rep 2 |
| GSM1281333 |
WT Lineage negative fetal liver cells E15.5, rep 3 |
| GSM1281334 |
Geminin-KO Lineage negative fetal liver cells E15.5, rep1 |
| GSM1281335 |
Geminin-KO Lineage negative fetal liver cells E15.5, rep2 |
| GSM1281336 |
Geminin-KO Lineage negative fetal liver cells E15.5, rep3 |
|
| Relations |
| BioProject |
PRJNA230779 |
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