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| Status |
Public on Nov 27, 2014 |
| Title |
Genome-wide analysis of gene expression in wild-type and Sp4 hypomorphic mouse cerebellum |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Transcription factor Sp4 controls dendritic patterning during development of cerebellar granule neurons in culture by limiting branch formation and promoting activity-dependent pruning (Ramos et al., 2007). Sp4 is associated with neuropsychiatric disorders such as major depressive disorder, schizophrenia and bipolar disorder. In order to identify target genes of Sp4, we compared global gene expression in the cerebella of wild type and Sp4 hypomorph mice (Sp4neo-/-; Zhou et al, 2005). The results identify candidate Sp4 target genes that may contribute to neuronal development and neuropsychiatric disorders.
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| Overall design |
Total RNA from postnatal Day 21 cerebella of 3 pairs of WT and Sp4 hypomorphic littermate mice were compared.
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| Contributor(s) |
Gill G, Sun X |
| Citation(s) |
25045015 |
| |
| Submission date |
Dec 06, 2013 |
| Last update date |
Jan 16, 2019 |
| Contact name |
Grace Gill |
| Organization name |
Tufts University
|
| Department |
Genetics Program
|
| Street address |
136 Harrison Ave
|
| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02111 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL6887 |
Illumina MouseWG-6 v2.0 expression beadchip |
|
| Samples (6)
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| Relations |
| BioProject |
PRJNA230783 |
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