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| Status |
Public on Nov 15, 2017 |
| Title |
Characterization of neuroendocrine tumors in heterozygous mutant MENX rats: a novel model of invasive medullary thyroid carcinoma [adrenal] |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
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| Summary |
As overwhelming evidence coming from transgenic mouse models but also from MEN4 patients seem to suggest that loss or inactivation of a single p27 allele plays an important role in neuroendocrine tumorigenesis, we decided to perform a detailed analysis of the phenotype of rats heterozygous for the MENX-associated germline Cdkn1b mutation.
We here show that the reduction to a single functional p27 allele predisposes MENX heterozygous rats to the development of neuroendocrine malignancies.
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| Overall design |
We compared 2 different groups: adrenal gland from wild type rats and adrenal lesions from heterozygous p27Kip1/Cdknb1 mutant rats.
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| Contributor(s) |
Molatore S, Irmler M, Beckers J, Pellegata N |
| Citation(s) |
29142006 |
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| Submission date |
Dec 16, 2013 |
| Last update date |
Mar 20, 2019 |
| Contact name |
Johannes Beckers |
| E-mail(s) |
johannes.beckers@helmholtz-munich.de
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| Organization name |
Helmholtz Zentrum Muenchen
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| Department |
Institute of Experimental Genetics
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| Street address |
Ingolstaedter Landstr. 1
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| City |
Neuherberg |
| ZIP/Postal code |
85764 |
| Country |
Germany |
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| Platforms (1) |
| GPL6247 |
[RaGene-1_0-st] Affymetrix Rat Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (11)
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| GSM1290135 |
Adrenal lesion, heterozygous for Cdknb1 mutation, biological replicate 1 |
| GSM1290136 |
Adrenal lesion, heterozygous for Cdknb1 mutation, biological replicate 2 |
| GSM1290137 |
Adrenal lesion, heterozygous for Cdknb1 mutation, biological replicate 3 |
| GSM1290138 |
Adrenal lesion, heterozygous for Cdknb1 mutation, biological replicate 4 |
| GSM1290139 |
Adrenal lesion, heterozygous for Cdknb1 mutation, biological replicate 5 |
| GSM1290140 |
Adrenal lesion, heterozygous for Cdknb1 mutation, biological replicate 6 |
| GSM1290141 |
Adrenal lesion, heterozygous for Cdknb1 mutation, biological replicate 7 |
| GSM1290142 |
Adrenal gland, biological replicate 1 |
| GSM1290143 |
Adrenal gland, biological replicate 2 |
| GSM1290144 |
Adrenal gland, biological replicate 3 |
| GSM1290145 |
Adrenal gland, biological replicate 4 |
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| Relations |
| BioProject |
PRJNA231843 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE53365_RAW.tar |
42.3 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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