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| Status |
Public on Mar 04, 2015 |
| Title |
Expression data of lungs from chickens infected with different H5N1 Avian Influenza Viruses [12 hours post infection] |
| Organism |
Gallus gallus |
| Experiment type |
Expression profiling by array
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| Summary |
Recently, a novel protein in the influenza virus segment 3 has been identified, namely PA-X. This small protein has been reported to play a role in modulating host response of the 1918 H1N1 pandemic virus-infected mice. However, poteinal role of this protein in the pathogenicity and regulating host response of the highly pathogenic H5N1 virus in a chicken animal model is completely unknown.
We used microarray analysis to evaluate the global transcriptional response in the lungs of the chickens infected with the parental strain (CK10) and PA-X deficiency mutant strain (CK-PAX3).
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| Overall design |
Chickens were inoculated with CK10 or CK-PAX3 or mock-infected. At 12 hours post infection, lungs were isolated from three chickens per group for RNA extraction and hybridization on Affymetrix microarrays. Samples were named as follows: CK10 (CK10-1,CK10-2,CK10-3), CK-PAX3 (CK-PAX3-1,CK-PAX3-2, CK-PAX3-3), Control (C-1, C-2, C-3).
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| Contributor(s) |
Hu J, Hu Z |
| Citation(s) |
25631083 |
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| Submission date |
Jan 09, 2014 |
| Last update date |
Mar 04, 2015 |
| Contact name |
Jiao Hu |
| E-mail(s) |
hujiao@yzu.edu.cn
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| Organization name |
Yangzhou University
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| Street address |
48 Wenhui Road
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| City |
Yangzhou |
| ZIP/Postal code |
225009 |
| Country |
China |
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| Platforms (1) |
| GPL3213 |
[Chicken] Affymetrix Chicken Genome Array |
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| Samples (9)
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| This SubSeries is part of SuperSeries: |
| GSE53932 |
Expression data of lungs from chickens infected with different H5N1 Avian Influenza Viruses |
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| Relations |
| BioProject |
PRJNA233995 |
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