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| Status |
Public on Jan 14, 2014 |
| Title |
CD40-activation of human B cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Antibody-independent effector functions of B cells, such as antigen presentation and cytokine production, have been shown to play an important role in a variety of immune-mediated conditions such as autoimmune diseases, transplant rejection and graft-versus-host disease. Therapeutic strategies, which interfere with B cell activation could therefore be a useful addition to the current immunosuppressive armamentarium. CD40 is one of the strongest activation stimuli for B cells. The aim of this study was to characterise the gene expression changes that occurr after B cell activation via CD40.
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| |
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| Overall design |
Purified B cells isolated from PBMCs from four donors were compared to B cells which
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| Contributor(s) |
Shimabukuro-Vornhagen A, Draube A, Popov A |
| Citation(s) |
25311809 |
| |
| Submission date |
Jan 13, 2014 |
| Last update date |
Aug 10, 2018 |
| Contact name |
Alexander Shimabukuro-Vornhagen |
| Organization name |
University Hospital of Cologne
|
| Department |
Department I of Internal Medicine
|
| Lab |
Cologne Interventional Immunology
|
| Street address |
Kerpener Str. 62
|
| City |
Cologne |
| ZIP/Postal code |
50674 |
| Country |
Germany |
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| Platforms (1) |
| GPL96 |
[HG-U133A] Affymetrix Human Genome U133A Array |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA234360 |
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