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| Status |
Public on Mar 11, 2014 |
| Title |
a-CGH of Esophageal Cancer (53 cases) |
| Organism |
Homo sapiens |
| Experiment type |
Genome variation profiling by genome tiling array
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| Summary |
Esophageal cancer is one of the most aggressive cancers and the sixth leading cause of cancer death worldwide. Approximately 70% of the global esophageal cancers occur in China and over 90% histopathological forms of this disease are esophageal squamous cell carcinoma (ESCC). Currently, there are limited clinical approaches for early diagnosis and treatment for ESCC, resulting in a 10% 5-year survival rate for the patients. Meanwhile, the full repertoire of genomic events leading to the pathogenesis of ESCC remains unclear. Here we show a comprehensive genomic analysis in 158 ESCC cases, as part of the International Cancer Genome Consortium (ICGC) Research Projects (http://icgc.org/icgc/cgp/72/371/1001734). We conducted whole-genome sequencing in 17 ESCC cases and whole-exome sequencing in 71 cases, of which 53 cases and additional 70 ESCC cases were subjected to array comparative genomic hybridization (a-CGH) analysis.
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| Overall design |
We conducted whole-genome sequencing in 17 ESCC cases and whole-exome sequencing in 71 cases, of which 53 cases and additional 70 ESCC cases were subjected to array comparative genomic hybridization (a-CGH) analysis.
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| Contributor(s) |
Zhan Q, Song Y, Li L, Ou Y, Gao Z |
| Citation(s) |
24670651 |
| Submission date |
Feb 13, 2014 |
| Last update date |
Jun 10, 2014 |
| Contact name |
Lin Li |
| E-mail(s) |
lilin@genomics.cn
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| Organization name |
BGI
|
| Street address |
Beishan Industrial Zone
|
| City |
shenzhen |
| ZIP/Postal code |
518083 |
| Country |
China |
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| Platforms (1) |
| GPL15436 |
NimbleGen Human CGH 3x720K Whole-Genome Tiling v3.0 Array [090527_HG18_WG_CGH_v3.1_HX3] |
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| Samples (53)
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| This SubSeries is part of SuperSeries: |
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| Relations |
| BioProject |
PRJNA238220 |
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