|
| Status |
Public on Feb 27, 2014 |
| Title |
Expression data from rhesus macaque jejunum |
| Organism |
Macaca mulatta |
| Experiment type |
Expression profiling by array
|
| Summary |
The mucosa that lines the gastrointestinal (GI) tracts is an important portal of entry for pathogens and provides the frontline of immune defense against HIV infection. Epithelial barrier dysfunction during HIV infection has largely been attributed to the rapid and severe depletion of CD4 T cells in the gastrointestinal (GI) tract. In this study, the poential role of small non-coding microRNA (miRNA) to contribute to epithelial dysfunction was investigated in the non-human primate SIV model and microarrays were utilized to determine changes in mucosal gene expression (non-miRNA) that could be correlated to miRNA modulatiolns.
Microarrays were used to characterize changes in gene expression in the jejunal mucosa that occur during chronic SIV infection
|
| |
|
| Overall design |
Jejunum tissues from healthy uninfected macaques and macaques with chronic stage SIV infection were used for RNA extraction and hybridization on Affymetrix microarrays.
|
| |
|
| Contributor(s) |
George MD |
| Citation(s) |
24672033 |
| |
| Submission date |
Feb 26, 2014 |
| Last update date |
Jun 02, 2014 |
| Contact name |
Michael George |
| E-mail(s) |
mdgeorge@ucdavis.edu
|
| Organization name |
University of California, Davis
|
| Department |
Medical Microbiology and Immunology
|
| Street address |
451 Health Sciences Drive
|
| City |
Davis |
| State/province |
CA |
| ZIP/Postal code |
95616 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL3535 |
[Rhesus] Affymetrix Rhesus Macaque Genome Array |
|
| Samples (6)
|
| GSM1334680 |
Jejunum tissue: SIV infected, untreated macaque biological rep 1 [JEJ NT 30085] |
| GSM1334681 |
Jejunum tissue: SIV infected, untreated macaque biological rep 2 [JEJ NT 31353] |
| GSM1334682 |
Jejunum tissue: SIV infected, untreated macaque biological rep 3 [JEJ NT 34030] |
| GSM1334683 |
Jejunum tissue: healthy uninfected macaque biological rep 1 [JEJ UI 33675] |
| GSM1334684 |
Jejunum tissue: healthy uninfected macaque biological rep 2 [JEJ UI 33842] |
| GSM1334685 |
Jejunum tissue: healthy uninfected macaque biological rep 3 [JEJ UI 34249] |
|
| Relations |
| BioProject |
PRJNA239409 |
Less...
More...