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| Status |
Public on Nov 30, 2015 |
| Title |
Genome-wide maps of PARP-1-bound nucleosomes. |
| Organism |
Drosophila melanogaster |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
PARP-1 binds to specific nucleosomes to regulate gene activity. While PARP-1's role in transcription inititaion is known, a surprising finding here was that PARP-1 is highly enriched at exon-intron and intron-exon boundaries, sort of demarcting exons. This indicating a role in alternative splicing.
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| |
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| Overall design |
ChIP-seq of PARP1-bound nucleosomes as well as MNase-seq of total nucleosome in Drosophila S2 cells
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| |
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| Contributor(s) |
Matveeva E, Maiorano J, Zhang Q, Abdallah E, Convertini P, Rouchka E, Stamm S, Wang J, Fondufe-Mitteendorf Y |
| Citation(s) |
27462443 |
|
Elena Matveeva, John Maiorano, Qingyang Zhang, AbdallahMEteleeb, Paolo Convertini, Jing Chen, Vittoria Infantino, Stefan Stamm, Jiping Wang, Eric C Rouchka, Yvonne N Fondufe-Mittendorf. Involvement of PARP1 in the regulation of alternative splicing. Cell Discovery (2016) 2, 15046; http://dx.doi.org/10.1038/celldisc.2015.46
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| |
| Submission date |
Mar 24, 2014 |
| Last update date |
Jul 24, 2019 |
| Contact name |
Yvonne Nsokika Fondufe-Mittendorf |
| E-mail(s) |
y.fondufe-mittendorf@uky.edu
|
| Phone |
8593230091
|
| Organization name |
University of Kentucky
|
| Department |
Biochemistry
|
| Lab |
Mittendorf
|
| Street address |
741 South Limestone dr.
|
| City |
Lexington |
| State/province |
KY |
| ZIP/Postal code |
40536-0509 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL14601 |
AB SOLiD 4 System (Drosophila melanogaster) |
|
| Samples (5)
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| Relations |
| BioProject |
PRJNA242505 |
| SRA |
SRP040493 |
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