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Series GSE57480 Query DataSets for GSE57480
Status Public on Jun 18, 2014
Title Inducible PAX5 expression in a human B lymphoblastic leukemia cell line
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Hypomorphic mutations of the transcription factor PAX5 occur in one third of B-progenitor acute lymphoblastic leukemias (B-ALLs). To identify PAX5-regulated genes in B-ALL, here we employ inducible expression of PAX5 in a human B-ALL cell line (REH) that harbors a loss-of-function mutation in PAX5. In this model, inducing PAX5 expression is associated with competitive disadvantage.
Overall design Comparison of REH cell lines with Dox-inducible expression of PAX5-IRES-GFP, or control GFP alone. GFP positive cells were isolated by FACS.
Contributor(s) Jude JG, Zuber J, Hu Y, Smyth GK
Citation(s) 24939936
Submission date May 08, 2014
Last update date May 15, 2019
Contact name Gordon K Smyth
Phone (+61 3) 9345 2326
Fax (+61 3) 9347 0852
Organization name Walter and Eliza Hall Institute of Medical Research
Department Bioinformatics
Lab Smyth
Street address 1G Royal Pde
City Parkville
State/province Vic
ZIP/Postal code 3052
Country Australia
Platforms (1)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
Samples (2)
GSM1383565 RNA-seq PAX5
GSM1383566 RNA-seq ctrl
BioProject PRJNA246532
SRA SRP041820

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE57480_Pax5Human-GenewiseCounts.txt.gz 189.4 Kb (ftp)(http) TXT
GSE57480_RAW.tar 330.0 Kb (http)(custom) TAR (of TXT)
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Raw data are available in SRA
Processed data provided as supplementary file
Processed data are available on Series record

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