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| Status |
Public on Sep 01, 2014 |
| Title |
Expression profiling of tumor cells from MYCN-driven neuroblastoma upon BRD4 or AURKA inhibition |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Amplification of MYCN is the most prominent genetic marker of high-stage neuroblastoma, a childhood tumor originating from the neural crest. We generated a cell line (mNB-A1) from tumors developed in transgenic mouse and treated these cells with DMSO (n=6), the BRD4-inhibitor JQ1 (n=3) or the AURKA-inhibitor MLN8237 (n=3) for 24 h.
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| Overall design |
The expression profiles of vehicle (DMSO)-treated mNB-A1 cells were compared to JQ1- or MLN8237-treated mNB-A1 cells.
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| Contributor(s) |
Schramm A, Schulte J, Althoff K |
| Citation(s) |
25174395 |
| |
| Submission date |
May 19, 2014 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Alexander Schramm |
| E-mail(s) |
alexander.schramm@uk-essen.de
|
| Organization name |
University Hospital Essen
|
| Department |
Childrens Hospital
|
| Lab |
Hematology/Oncology Lab
|
| Street address |
Hufelandstr. 55
|
| City |
Essen |
| ZIP/Postal code |
45122 |
| Country |
Germany |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA248139 |
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