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Series GSE57920 Query DataSets for GSE57920
Status Public on May 23, 2014
Title Using C. intestinalis to study Islet in ascidian palp morphogenesis
Organism Ciona intestinalis
Experiment type Expression profiling by array
Summary In Ciona intestinalis, the palps consist of three conical protrusions within a field of thickened epithelium that form late in embryogenesis as tailbuds mature into larvae. The palp protrusions express the LIM-homeodomain transcription factor Islet. Protrusion occurs through differential cell elongation, likely mediated by Islet, as we find that ectopic expression of Islet is sufficient to promote cell elongation. FGF signaling is required for both Islet expression and palp morphogenesis. Importantly, we show that Islet expression can rescue the palp-deficient phenotype that results from inhibition of FGF signaling. We conclude that Islet is a key regulatory factor governing morphogenesis of the palps. It is conceivable that Islet is also essential for the cellular morphogenesis of placode-derived sensory neurons in vertebrates.
Islet expression can rescue the palp-deficient phenotype that results from inhibition of FGF signaling, and conclude that Islet is a key regulatory factor governing morphogenesis of the palps.
 
Overall design Three biological replicates were analyzed for both sample types (Fox positive and Negative).
 
Contributor(s) Wagner E, Stolfi A, Choi YG, Levine M
Citation(s) 24993943
Submission date May 22, 2014
Last update date Sep 11, 2014
Contact name Justin Choi
E-mail(s) jygchoi@berkeley.edu
Phone 510-642-1165
Organization name UC Berkeley
Department Functional Genomics lab
Street address 255 Life Sciecnces Addition
City Berkeley
State/province CA
ZIP/Postal code 94720
Country USA
 
Platforms (1)
GPL15657 [CINT06a520380F] Affymetrix Ciona intestinalis custom-designed array
Samples (6)
GSM1397452 FC1
GSM1397453 FC2
GSM1397454 FC3
Relations
BioProject PRJNA248413

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE57920_RAW.tar 25.3 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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