GEO Accession viewer

NCBI > GEO > Accession Display

Not logged in | Login

GEO help: Mouse over screen elements for information.

Series GSE581

Query DataSets for GSE581

Status

Public on Jan 07, 2004

Title

Inflammatory gene profiles in human gastric mucosa

Organism

Homo sapiens

Experiment type

Expression profiling by array

Summary

Helicobacter pylori (H. pylori) infection is associated with an inflammatory response in the gastric mucosa, ultimately leading to cellular hyperproliferation and malignant transformation. Hitherto, only expression of a single gene, or a limited number of genes, has been investigated in infected patients. Thus, the impact of H. pylori on the expression of a broad set of genes has not yet been analyzed. cDNA arrays were therefore used to establish the global pattern of gene expression in gastric tissue of healthy subjects and of H. pylori infected patients. Two main gene expression profiles were identified based on cluster analysis. The data obtained suggest a strong involvement of selected Toll-like receptors (TLRs)3, adhesion molecules, chemokines, and interleukins in the mucosal response. This pattern is clearly different from that observed using gastric epithelial cell lines infected in vitro with H. pylori. The genotype of the bacteria (presence of genes encoding CagA, VacA and BabA) was analyzed by PCR and shown to be associated with different expression profiles. The presence of a
Keywords = H. pylori
Keywords = gastric inflammation
Keywords = cytokines
Keywords: parallel sample

Contributor(s)

Wen S, Pan-Hammarström Q

Citation(s)

14764733

Submission date

Aug 08, 2003

Last update date

Feb 23, 2012

Contact name

Qiang Pan-Hammarström

E-mail(s)

Qiang.Pan-Hammarstrom@ki.se