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| Status |
Public on Jun 20, 2014 |
| Title |
Expression data of wild type and C-DGCR8 KO cones at different timepoints [array] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
We have analyzed gene expression in cone photoreceptors isolated from wild type and C-DGCR8 (DiGeorge Syndrome Critical Region Gene 8) KO mice at five different time points to get a mechanistic inside into the altered molecular pathways after microRNAs depletion.
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| Overall design |
Cones were isolated by FACS from wild type and C-DGCR8 KO mice expressing Cre recombinase postnatally specifically in cones (D4-Cre) and bearing conditional null Dgcr8 allele. Experiments were performed in duplicates from different time points (P30, P40, P50, P60, and P90). Total RNA was extracted and hybridization on Affymetrix array was performed.
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| Contributor(s) |
Krol J, Busskamp V, Roska B, Filipowicz W |
| Citation(s) |
25002228 |
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| Submission date |
Jun 13, 2014 |
| Last update date |
Mar 04, 2019 |
| Contact name |
Tim Roloff |
| E-mail(s) |
tim.roloff@fmi.ch
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| Organization name |
FMI
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| Department |
Functional Genomics
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| Street address |
Maulbeerstrasse 66
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| City |
Basel |
| ZIP/Postal code |
4058 |
| Country |
Switzerland |
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| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (20)
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| GSM1412530 |
P40_wt cones, replicate 2 [array] |
| GSM1412531 |
P50_wt cones, replicate 1 [array] |
| GSM1412532 |
P50_wt cones, replicate 2 [array] |
| GSM1412533 |
P60_wt cones, replicate 1 [array] |
| GSM1412534 |
P60_wt cones, replicate 2 [array] |
| GSM1412535 |
P90_wt cones, replicate 1 [array] |
| GSM1412536 |
P90_wt cones, replicate 2 [array] |
| GSM1412537 |
P30_C-DGCR8 KO cones, replicate 1 [array] |
| GSM1412538 |
P30_C-DGCR8 KO cones, replicate 2 [array] |
| GSM1412539 |
P40_C-DGCR8 KO cones, replicate 1 [array] |
| GSM1412540 |
P40_C-DGCR8 KO cones, replicate 2 [array] |
| GSM1412541 |
P50_C-DGCR8 KO cones, replicate 1 [array] |
| GSM1412542 |
P50_C-DGCR8 KO cones, replicate 2 [array] |
| GSM1412543 |
P60_C-DGCR8 KO cones, replicate 1 [array] |
| GSM1412544 |
P60_C-DGCR8 KO cones, replicate 2 [array] |
| GSM1412545 |
P90_C-DGCR8 KO cones, replicate 1 [array] |
| GSM1412546 |
P90_C-DGCR8 KO cones, replicate 2 [array] |
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| This SubSeries is part of SuperSeries: |
| GSE58501 |
MiRNAs 182 and 183 are necessary to maintain adult cone photoreceptor outer segments and visual function |
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| Relations |
| BioProject |
PRJNA253148 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE58493_RAW.tar |
82.5 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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