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| Status |
Public on Jun 16, 2014 |
| Title |
Intratumoral heterogeneity of colorectal cancers with distant metastases |
| Organism |
Homo sapiens |
| Experiment type |
Genome variation profiling by genome tiling array
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| Summary |
Copy number analyses of regionally separated biopsies from primary and metastatic lesions of five colorectal cancers
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| Overall design |
A total of 35 intratumoral biopsies were obtained from primary and metastatic lesions of five colorectal cancers. Board-certified pathologists reviewed the hematoxylin&eosin stained sections and identified tumor-rich regions (> 80% purity) to ensure minimal contamination of normal tissues. We selected two to six different areas for biopsy that were at least 5mm apart in primary and distant metastatic lesions from a same patient. Copy number profiling was performed using Agilent 180K platform according to the manufacturer's protocol. The genomic DNA obtained from the adjacent normal tissues were used as reference genomic DNA for the tumor DNA of the corresponding patients.
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| Contributor(s) |
Kim T, Chung Y, Lee S |
| Citation(s) |
25979483 |
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| Submission date |
Jun 16, 2014 |
| Last update date |
Nov 03, 2015 |
| Contact name |
Tae-Min Kim |
| E-mail(s) |
tmkim@catholic.ac.kr
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| Phone |
82-2-2258-7753
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| Organization name |
The Catholic University of Korea, College of Medicine
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| Department |
Dept of Medical Informatics
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| Street address |
Seocho-Gu, Banpo-Dong
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| City |
Seoul |
| ZIP/Postal code |
137-701 |
| Country |
South Korea |
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| Platforms (1) |
| GPL10123 |
Agilent-022060 SurePrint G3 Human CGH Microarray 4x180K (Feature Number version) |
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| Samples (35)
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| GSM1412783 |
Intratumoral heterogeneity of colorectal cancers, patient 1, biopsy 1, primary |
| GSM1412784 |
Intratumoral heterogeneity of colorectal cancers, patient 1, biopsy 2, primary |
| GSM1412785 |
Intratumoral heterogeneity of colorectal cancers, patient 1, biopsy 3, primary |
| GSM1412786 |
Intratumoral heterogeneity of colorectal cancers, patient 1, biopsy 4, primary |
| GSM1412787 |
Intratumoral heterogeneity of colorectal cancers, patient 1, biopsy 1, metastasis |
| GSM1412788 |
Intratumoral heterogeneity of colorectal cancers, patient 1, biopsy 2, metastasis |
| GSM1412789 |
Intratumoral heterogeneity of colorectal cancers, patient 1, biopsy 3, metastasis |
| GSM1412790 |
Intratumoral heterogeneity of colorectal cancers, patient 2, biopsy 1, primary |
| GSM1412791 |
Intratumoral heterogeneity of colorectal cancers, patient 2, biopsy 2, primary |
| GSM1412792 |
Intratumoral heterogeneity of colorectal cancers, patient 2, biopsy 3, primary |
| GSM1412793 |
Intratumoral heterogeneity of colorectal cancers, patient 2, biopsy 4, primary |
| GSM1412794 |
Intratumoral heterogeneity of colorectal cancers, patient 2, biopsy 5, primary |
| GSM1412795 |
Intratumoral heterogeneity of colorectal cancers, patient 2, biopsy 1, metastasis |
| GSM1412796 |
Intratumoral heterogeneity of colorectal cancers, patient 2, biopsy 2, metastasis |
| GSM1412797 |
Intratumoral heterogeneity of colorectal cancers, patient 3, biopsy 1, primary |
| GSM1412798 |
Intratumoral heterogeneity of colorectal cancers, patient 3, biopsy 2, primary |
| GSM1412799 |
Intratumoral heterogeneity of colorectal cancers, patient 3, biopsy 3, primary |
| GSM1412800 |
Intratumoral heterogeneity of colorectal cancers, patient 3, biopsy 4, primary |
| GSM1412801 |
Intratumoral heterogeneity of colorectal cancers, patient 3, biopsy 5, primary |
| GSM1412802 |
Intratumoral heterogeneity of colorectal cancers, patient 3, biopsy 1, metastasis |
| GSM1412803 |
Intratumoral heterogeneity of colorectal cancers, patient 3, biopsy 2, metastasis |
| GSM1412804 |
Intratumoral heterogeneity of colorectal cancers, patient 3, biopsy 3, metastasis |
| GSM1412805 |
Intratumoral heterogeneity of colorectal cancers, patient 3, biopsy 4, metastasis |
| GSM1412806 |
Intratumoral heterogeneity of colorectal cancers, patient 3, biopsy 5, metastasis |
| GSM1412807 |
Intratumoral heterogeneity of colorectal cancers, patient 3, biopsy 6, metastasis |
| GSM1412808 |
Intratumoral heterogeneity of colorectal cancers, patient 4, biopsy 1, primary |
| GSM1412809 |
Intratumoral heterogeneity of colorectal cancers, patient 4, biopsy 2, primary |
| GSM1412810 |
Intratumoral heterogeneity of colorectal cancers, patient 4, biopsy 1, metastasis |
| GSM1412811 |
Intratumoral heterogeneity of colorectal cancers, patient 4, biopsy 2, metastasis |
| GSM1412812 |
Intratumoral heterogeneity of colorectal cancers, patient 4, biopsy 3, metastasis |
| GSM1412813 |
Intratumoral heterogeneity of colorectal cancers, patient 4, biopsy 4, metastasis |
| GSM1412814 |
Intratumoral heterogeneity of colorectal cancers, patient 5, biopsy 1, primary |
| GSM1412815 |
Intratumoral heterogeneity of colorectal cancers, patient 5, biopsy 2, primary |
| GSM1412816 |
Intratumoral heterogeneity of colorectal cancers, patient 5, biopsy 1, metastasis |
| GSM1412817 |
Intratumoral heterogeneity of colorectal cancers, patient 5, biopsy 2, metastasis |
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| Relations |
| BioProject |
PRJNA252805 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE58512_RAW.tar |
658.9 Mb |
(http)(custom) |
TAR (of TXT) |
| Processed data included within Sample table |
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