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GEO help: Mouse over screen elements for information. |
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Status |
Public on Dec 10, 2007 |
Title |
Gene expression profiles in TNBS-induced murine colitis |
Organism |
Mus musculus |
Experiment type |
Expression profiling by array
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Summary |
We investigated the relationship between chronic inflammation and fibrosis in a mouse model of chronic colitis. Six weekly Trinitrobenzenesulphonic acid (TNBS) enemas were given to establish colitis and temporal changes in gene expression was elucidated over the next six weeks. Keywords: disease state analysis
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Overall design |
After the six TNBS enemas, mice were sacrificed at 3 days (termed as TNBS-w6, n=6), 2 weeks (TNBS-w8, n=4), 4 weeks (TNBS-w10, n=5), or 6 weeks (TNBS-w12, n=4). The saline control groups were also sacrificed at week 6 (Saline-w6, n=5), week 8 (n=2) and week 10 (n=2). The last two sets were pooled as Saline-w10 (n=4). Two replicates of saline-w6 were analyzed. We compared Saline-w6 with TNBS-w6, and Saline-w10 with TNBS-w8, TNBS-w10, TNBS-w12, respectively.
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Contributor(s) |
Wu F, Chakravarti S |
Citation(s) |
17982090 |
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Submission date |
Sep 18, 2006 |
Last update date |
Feb 18, 2018 |
Contact name |
Shukti Chakravarti |
E-mail(s) |
schakrav@jhmi.edu
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Phone |
410-502-7627
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Fax |
410-614-4834
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Organization name |
Johns Hopkins University School of Medicine
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Department |
Medicine
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Lab |
935 Ross Bldg/ GI division
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Street address |
720 Rutland Ave
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City |
Baltimore |
State/province |
MD |
ZIP/Postal code |
21205 |
Country |
USA |
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Platforms (1) |
GPL81 |
[MG_U74Av2] Affymetrix Murine Genome U74A Version 2 Array |
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Samples (7)
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Relations |
BioProject |
PRJNA97275 |
Supplementary data files not provided |
Processed data included within Sample table |
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