|
| Status |
Public on Mar 30, 2015 |
| Title |
Genome-wide analysis of ETS factor ER71/ETV2 chromatin occupancy |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
We discover that ER71/ETV2 initiates hemangiogenic program by activating blood and endothelial cell lineage specifying genes while enhancing FLK1 expression and expanding hemangioblast population. Furthermore, ER71/ETV2 establishes an ETS hierarchy by directly activating Ets genes in hematopoietic and endothelial cell lineage development. As such, ER71/ETV2-initiated blood and endothelial cell program is maintained by ER71/ETV2 downstream ETS factors through an ETS switching mechanism.
|
| |
|
| Overall design |
ChIP-seq analysis of ER71 in differentiated embryonic stem cells
|
| |
|
| Contributor(s) |
Liu F, Choi K, Li D, Wang T |
| Citation(s) |
25802403 |
| |
| Submission date |
Jul 14, 2014 |
| Last update date |
May 15, 2019 |
| Contact name |
Daofeng Li |
| E-mail(s) |
lidaof@gmail.com
|
| Phone |
(314) 286-0866
|
| Organization name |
Washington University in St. Louis
|
| Department |
Genetics
|
| Lab |
Ting Wang Lab
|
| Street address |
4515 McKinley Avenue
|
| City |
SAINT LOUIS |
| State/province |
MO |
| ZIP/Postal code |
63110 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL9250 |
Illumina Genome Analyzer II (Mus musculus) |
|
| Samples (6)
|
|
| Relations |
| BioProject |
PRJNA255249 |
| SRA |
SRP044310 |
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