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| Status |
Public on Jan 01, 2016 |
| Title |
Gene expression in rat ovaries treated with DHT |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
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| Summary |
Polycystic ovarian syndrome (PCOS) is an endocrine disorder of the reproductive and metabolic axis in women during the reproductive age. In this study, we used a rat model exhibiting reproductive and metabolic abnormalities similar to human PCOS to unravel the molecular mechanisms underlining this complex syndrome.
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| Overall design |
Female Sprague-Dawley rats were implanted with a silicone capsule continuous-releasing 5α-dehydrotestestrone (DHT) per day for 12 weeks to mimic the hyperandrogenic state in women with PCOS, and the control (CTL) groups received an empty capsule. The animals were euthanized at 15 weeks of age and the ovarian cortex tissues of both groups were used for transcriptome profile analysis.
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| Contributor(s) |
Salilew-Wondim D, Wang Q, Tesfaye D, Schellander K, Hoelker M, Hussein M, Tsang BK |
| Citation(s) |
25887459 |
| |
| Submission date |
Jul 16, 2014 |
| Last update date |
Jul 31, 2017 |
| Contact name |
Dessie Salilew-Wondim |
| E-mail(s) |
dsalilew@uni-bonn.de
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| Organization name |
University of Bonn
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| Department |
Animal breeding and husbandry group
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| Street address |
Endenicher Allee 15
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| City |
Bonn |
| State/province |
NRW |
| ZIP/Postal code |
D-53115 |
| Country |
Germany |
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| Platforms (1) |
| GPL1355 |
[Rat230_2] Affymetrix Rat Genome 230 2.0 Array |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA255367 |
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