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Series GSE60006 Query DataSets for GSE60006
Status Public on Aug 02, 2014
Title Genome-wide maps of HES1 binding-site in human chondrogenic cell.
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary Notch signaling modulates skeletal formation and osteoarthritis (OA) development through induction of catabolic factors. Here we examined functional roles of Hes1, the representative downstream transcription factor of Notch signaling, during these processes. Chromatin immunoprecipitation-sequencing (ChIP-seq) identified resposive elements of Hes1 around gene loci of Mmp13 and Adamts5, which were catabolic enzymes of cartilage matrix.
Overall design Examination of HES1 binding site in human chondrogenic SW1353 cells.
Contributor(s) Sugita S, Saito T
Citation(s) 25733872
Submission date Aug 01, 2014
Last update date May 15, 2019
Contact name Shurei Sugita
Organization name The University of Tokyo
Department Sensory & Motor System Medicine
Street address 7-3-1, Hongo, Bunkyo-ku
City Tokyo
ZIP/Postal code 113-8655
Country Japan
Platforms (1)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
Samples (1)
GSM1463456 PG0198_A01
BioProject PRJNA257267
SRA SRP045174

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Supplementary file Size Download File type/resource
GSE60006_RAW.tar 1.3 Gb (http)(custom) TAR (of BED, BEDGRAPH, XLSX)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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