|
| Status |
Public on Jan 30, 2015 |
| Title |
RNA-seq analysis of withdrawal of miR-155 hyperexpression in miR-155-addicted tumors |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Overexpression of miR-155 in hematological tissue leads to the onset of lymphoma, and Tet-off shutdown of this overexpression reverses the disease phenotype in mir-155LSLtTA mice. This study compares the gene expression profiles of tumors with miR-155 overexpression and withdrawal.
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| |
|
| Overall design |
Examination of mRNA from 2 conditions: miR-155 overexpressing tumors and miR-155 overexpressing tumors from mice exposed to doxycycline (DOX) for 16hrs prior to harvest; samples in triplicate; tumors generated in flanks of nude mice by subcutaneous injection of splenic cells from diseased mir-155LSLtTA mice.
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| |
|
| Contributor(s) |
Cheng CJ, Slack FJ |
| Citation(s) |
25409146 |
| Submission date |
Sep 29, 2014 |
| Last update date |
May 15, 2019 |
| Contact name |
Christopher J Cheng |
| E-mail(s) |
christopher.cheng@yale.edu
|
| Organization name |
Yale University
|
| Street address |
55 Prospect St
|
| City |
New Haven |
| State/province |
CT |
| ZIP/Postal code |
06511 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL13112 |
Illumina HiSeq 2000 (Mus musculus) |
|
| Samples (6)
|
|
| Relations |
| BioProject |
PRJNA262555 |
| SRA |
SRP048246 |
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