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Series GSE6188 Query DataSets for GSE6188
Status Public on Feb 18, 2008
Title Distinctive microRNA profiles relating to patient survival in esophageal squamous cell carcinoma
Platform organisms Homo sapiens; Mus musculus; Rattus norvegicus
Sample organism Homo sapiens
Experiment type Non-coding RNA profiling by array
Summary We have investigated expressed microRNA in cryo-preserved esophageal cancer tissues using advanced microRNA microarray techniques. Our microarray analyses reveal a unique microRNA expression signature composed of 40 genes which can distinguish normal from malignant esophageal tissue. Some microRNAs could be correlated with the different clinico-pathological classifications. For example, high hsa-miR-103, -107, -23b expression correlated with poor overall disease-free survival of esophageal cancer patients. These results indicate that microRNA expression profiles are important diagnostic and prognostic markers of esophageal cancer, which might be analyzed simply using economical approaches such as RT-PCR.
Keywords: microRNA, esophageal squamous cell carcinoma
 
Overall design cancer vs adjacent normal tissues
 
Contributor(s) Guo Y
Citation(s) 18172293
Submission date Oct 30, 2006
Last update date Mar 17, 2012
Contact name yong guo
E-mail(s) yongguo@tsinghua.edu.cn
Phone (86)-10-62796071
Fax (86)-10-62773059
Organization name Tsinghua University
Department Medical Systems Biology Research Center
Street address Qinghuayuan
City Beijing
State/province Beijing
ZIP/Postal code 100084
Country China
 
Platforms (1)
GPL4508 Tsinghua University mammalian 2K microRNA microarray
Samples (257)
GSM143030 Adjacent normal tissue from patient 215270-1
GSM143031 Adjacent normal tissue from patient 215270-2
GSM143032 Adjacent normal tissue from patient 207367-1
Relations
BioProject PRJNA100663

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE6188_RAW.tar 20.4 Mb (http)(custom) TAR (of GPR)
Processed data included within Sample table

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