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| Status |
Public on Oct 01, 2019 |
| Title |
Differentially expressed genes in Naa10p knockout mouse embryos |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Mammalian Naa10p, encoded by NAA10, is the only known enzyme capable of catalyzing both N-α-acetylation of nascent proteins in cytosol and ε-acetylation of internal lysines of proteins. Both enzyme-dependent and -independent functions of Naa10p are associated with cancer and some genetic diseases with developmental defects. To examine the function of Naa10p in development, we generated Naa10-KO mice by deleting exons 2 to 6 of Naa10 gene, which encode all putative isoforms of Naa10p. RNA sequencing (RNA-seq) analysis of 2 WT and 2 Naa10p-KO embryos from the same litter was performed.
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| Overall design |
mRNA profiles of 2 Naa10-KO and 2 littermate WT embryos were generated by deep sequencing, using Illumina HiSeq 2000.
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| Contributor(s) |
Juan LJ, Lee CC, Peng SH |
| Citation missing |
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| |
| Submission date |
Oct 03, 2014 |
| Last update date |
Oct 01, 2019 |
| Contact name |
Li-Jung Juan |
| E-mail(s) |
ljjuan@gate.sinica.edu.tw
|
| Phone |
+886-2-2787-1234
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| Organization name |
Academia Sinica
|
| Department |
Genomic Research Center
|
| Lab |
3L06
|
| Street address |
128 Academia Road, Section 2, Nankang
|
| City |
Taipei |
| ZIP/Postal code |
115 |
| Country |
Taiwan |
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| Platforms (1) |
| GPL13112 |
Illumina HiSeq 2000 (Mus musculus) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA262981 |
| SRA |
SRP048622 |
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