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| Status |
Public on Jun 01, 2016 |
| Title |
A restricted period for formation of Outer Subventricular Zone defined by Cdh1 and Trnp1 levels |
| Organism |
Mustela putorius furo |
| Experiment type |
Expression profiling by array
|
| Summary |
The Outer Subventricular Zone (OSVZ) is a germinal layer playing key roles in the development of the neocortex, with particular relevance in gyrencephalic species like human and ferret where it contains abundant basal Radial Glia Cells (bRGCs) that promote cortical expansion. Here we identify a brief period in ferret embryonic development when apical RGCs generate a burst of bRGCs that become founders of the OSVZ. After this period, bRGCs in the OSVZ proliferate and self-renew exclusively locally, thereby forming a self-sustained lineage independent from the other germinal layers. The time window for the brief period of OSVZ bRGC production is delineated by the coincident down-regulation of Cdh1 and Trnp1, and their up-regulation reduces bRGC production and prevents OSVZ seeding. This mechanism in cortical development may have key relevance in brain evolution and disease
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| Overall design |
Samples were analyzed with 3 replicates of each of them (except E34SVZ that has 2 replicantes). Comparisons were done taking different reference sample depending on the comparison.
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| Contributor(s) |
Martínez-Martínez MA, De Juan Romero C, Fernández V, Cárdenas A, Götz M, Borrell V |
| Citation(s) |
27264089, 35172154 |
| |
| Submission date |
Nov 12, 2014 |
| Last update date |
Mar 09, 2022 |
| Contact name |
Victor Borrell |
| E-mail(s) |
vborrell@umh.es
|
| Organization name |
CSIC
|
| Department |
Institute of Neuroscience
|
| Lab |
221
|
| Street address |
Av Ramon y Cajal s/n
|
| City |
San Juan de Alicante |
| State/province |
Alicante |
| ZIP/Postal code |
03550 |
| Country |
Spain |
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| Platforms (1) |
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| Samples (11)
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| Relations |
| BioProject |
PRJNA266982 |
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