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| Status |
Public on Sep 23, 2015 |
| Title |
A comprehensive epigenome map of Plasmodium falciparum reveals unique mechanisms of transcriptional regulation |
| Organism |
Plasmodium falciparum |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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| Summary |
Epigenetic mechanisms have been poorly understood in Plasmodium falciparum, the causative agent of malaria. To elucidate stage specific epigenetic regulations in P. falciparum, we performed genome-wide mapping of various histone modifications, nucleosomes and RNA Polymerase II. Our comprehensive analysis suggest that transcription initiation and elongation are distinct in Plasmodium. In this study, by analyzing histone modifications, nucleosome occupancy and RNA Polymerase II (Pol II) at three different IEC developmental stages of Plasmodium; ring, trophozoite and schizont, we tried to unravel the epigenetic mechanism associated with gene regulation.
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| Overall design |
Examination of H3K27me3, H3K4me3, H3K9me3, H3K14ac, H3K4me1, H3K79me3, H3K27ac, H3K4me2, H3K9ac, H4ac, RNA Pol II and Histone H3 at three different stages of Plasmodium falciparum
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| Contributor(s) |
Karmodiya K |
| Citation(s) |
26388940, 26981368 |
| Submission date |
Nov 17, 2014 |
| Last update date |
May 15, 2019 |
| Contact name |
Krishanpal Karmodiya |
| E-mail(s) |
krish@iiserpune.ac.in
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| Organization name |
Indian Institute of Science Education and Research
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| Department |
Center of Excellence in Epigenetics
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| Street address |
Dr. Homi Bhabha Road
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| City |
Pune |
| State/province |
Maharashtra |
| ZIP/Postal code |
411008 |
| Country |
India |
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| Platforms (1) |
| GPL19422 |
AB SOLiD 4 System (Plasmodium falciparum) |
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| Samples (39)
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| Relations |
| BioProject |
PRJNA267591 |
| SRA |
SRP049964 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE63369_RAW.tar |
6.3 Gb |
(http)(custom) |
TAR (of BED) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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