|
|
GEO help: Mouse over screen elements for information. |
|
Status |
Public on Dec 30, 2015 |
Title |
Comparative analysis of genome-wide gene expression profiles in heart, liver, spleen, ears and bone marrow in the murine strains of MRL/MpJ, C57B/6J, and Balb/C |
Organism |
Mus musculus |
Experiment type |
Expression profiling by array
|
Summary |
The MRL/MpJ mouse strain is known as a model of mammalian regeneration. The strain exhibits an unusual capacity in regenerative wound healing manifested by scarless ear-hole closure and enhanced regeneration response reported in other organs. A significant feature of the strain is that the adult MRL/MpJ mouse retains several embryonic biochemical characteristics, including increased expression of stem cell markers. As the regenerative response after injury is rather limited in mammals the MRL/MpJ mouse is a great model to study the molecular and cellular basis of scarless wound healing. We report here the analysis of genome-wide transcriptomic profiles in the heart, ear, spleen, liver and bone marrow of the MRL/MpJ mouse. We used gene expression microarray, which interrogates 44.170 of mouse transcripts, in order to identify the genes exhibiting remarkable differences in expression in the MRL/MpJ mouse compared to two reference strains: C57BL/6J and BALB/c. The comparison revealed hundreds of differentially expressed transcripts. Significant enrichments of genes engaged in retinol metabolism, peroxisome proliferator-activated receptor (PPAR), wound healing, and homeobox pathways distinguishes the differentially expressed transcripts up-regulated in the MRL/MpJ mouse, whereas the genes related to immune response, including including response to wounding are greatly enriched among those down-regulated. The same functional categories were associated with remarkable parallels between the transcriptomic patterns in murine neonates and the adult MRL/MpJ mouse.
|
|
|
Overall design |
15 samples, each sample is a poll representing three animals
|
|
|
Contributor(s) |
Sachadyn P |
Citation(s) |
26572684 |
|
Submission date |
Jan 02, 2015 |
Last update date |
Mar 31, 2016 |
Contact name |
Pawel Sachadyn |
E-mail(s) |
psach@pg.gda.pl
|
Phone |
+48 583471605
|
Organization name |
Gdansk University of Technology
|
Department |
Molecular Biotechnology and Microbiology
|
Street address |
Narutowicza 11/12
|
City |
Gdansk |
ZIP/Postal code |
80-233 |
Country |
Poland |
|
|
Platforms (1) |
GPL15887 |
NimbleGen Mouse gene expression array [100718_MM9_EXP] (gene-level version) |
|
Samples (15)
|
|
Relations |
BioProject |
PRJNA271474 |
Supplementary file |
Size |
Download |
File type/resource |
GSE64624_RAW.tar |
52.3 Mb |
(http)(custom) |
TAR (of PAIR) |
Processed data included within Sample table |
|
|
|
|
|