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| Status |
Public on Jan 07, 2016 |
| Title |
Hepatic transcriptome profiling of liver-specific Xbp1 knockout mice fed a high fat diet |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Xbp1 is an important regulator of unfolded protein response and lipid metabolism. Its dyregulation has been associcated in human NASH. Feeding a high fat diet with fructose/sucrose to mice causes progressive, fibrosing steatohepatitis. This study is to use RNA-Seq to identify differentially expressed genes in hepatic Xbp1 deficient mice livers fed with a high fat diet compared to controls.
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| |
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| Overall design |
Hepatic Xbp1 deficient mice or flox controls were fed either regular chow or a high fat diet (n=4). Samples from each cohort were pooled into two replicates.
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| |
|
| Contributor(s) |
Green R |
| Citation(s) |
26472223 |
| |
| Submission date |
Jan 09, 2015 |
| Last update date |
May 15, 2019 |
| Contact name |
Richard Green |
| E-mail(s) |
r-green2@northwestern.edu
|
| Organization name |
Northwestern University
|
| Street address |
Tarry 15, 303 E. Chicago Av.
|
| City |
Chicago |
| State/province |
IL |
| ZIP/Postal code |
60305 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL13112 |
Illumina HiSeq 2000 (Mus musculus) |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA271953 |
| SRA |
SRP051964 |
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