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Status |
Public on Apr 02, 2015 |
Title |
Gene expression of distinct lung dendritic cell subsets |
Organism |
Mus musculus |
Experiment type |
Expression profiling by array
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Summary |
Pulmonary dendritic cells are heterogenous cells comprise four distinct subsets including two conventional dendritic cell subsets, CD103+ and CD11bhiCD14lo cells, and two monocyte-derived dendritic cell subsets. Their functions in terms of migration and T cell activation are distinct, but genes regulating their features are to be determined. We used microarrays to identify a select set of genes that are expressed in conventinal dendritic cells and in monocyte-derived dendriti cells.
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Overall design |
Four distinct lung DC subsets were purified by flow cytometry-based sorting after inhalation of lipopolusaccharide and ovalbumin. Each subset has three replicates.
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Contributor(s) |
Nakano H, Cook D |
Citation(s) |
- Nakano H, Moran TP, Nakano K, Gerrish KE et al. Complement receptor C5aR1/CD88 and dipeptidyl peptidase-4/CD26 define distinct hematopoietic lineages of dendritic cells. J Immunol 2015 Apr 15;194(8):3808-19. PMID: 25769922
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Submission date |
Jan 12, 2015 |
Last update date |
Feb 11, 2019 |
Contact name |
NIEHS Microarray Core |
E-mail(s) |
microarray@niehs.nih.gov, liuliw@niehs.nih.gov
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Organization name |
NIEHS
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Department |
DIR
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Lab |
Microarray Core
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Street address |
111 T.W. Alexander Drive
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City |
RTP |
State/province |
NC |
ZIP/Postal code |
27709 |
Country |
USA |
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Platforms (1) |
GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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Samples (12)
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Relations |
BioProject |
PRJNA272431 |