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| Status |
Public on Jan 01, 2016 |
| Title |
Adiponectin-cre FTO flox/flox and FTO flox/flox mouse white fat tissues |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Single nucleotide polymorphisms in intron 1 of the fat mass and obesity-associated (FTO) gene were found to be associated with an increased risk of adult obesity. Enhanced FTO expression in mice leads to hyperphagia, increased fat mass, and higher body weight. Neuronal-specific FTO–deleted mice have an identical lean body weight phenotype to global FTO-deleted mice. The physiological role of adipose FTO in the homeostasis of energy regulation remains to be elucidated.
We used microarrays to elucidate the metabolic pathways that are regulated by FTO in the white fat.
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| Overall design |
FTO flox/flox and Adiponectin-cre FTO flox/flox (AFO) mice were fed with chow diet. White fat tissues from epididymal adipose pad were harvested under ad lib condition for RNA isolation. Three independent pools of FTO flox/flox and AFO mouse white fat RNA were included in the study.
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| |
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| Contributor(s) |
Wang C, Shie S, Wen M, Hung K, Hsieh I, Yeh T, Wu D |
| Citation(s) |
26671148 |
| |
| Submission date |
Jan 20, 2015 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Chao-Yung Wang |
| E-mail(s) |
cwang@ocean.ag
|
| Organization name |
Chang Gung Memorial Hospital
|
| Department |
Cardiology
|
| Lab |
OCEAN
|
| Street address |
5 Fu-Hsing street
|
| City |
Taoyuan |
| ZIP/Postal code |
333 |
| Country |
Taiwan |
| |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA272993 |
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