|
| Status |
Public on Aug 01, 2015 |
| Title |
MicroRNA profiling of neurons generated using induced pluripotent stem cells derived from patients with schizophrenia and 22q11.2 deletion |
| Organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by high throughput sequencing
|
| Summary |
We are using induced pluripotent stem cell (iPSC) technology to study neuropsychiatric disorders associated with 22q11.2 microdeletions (del), the most common known schizophrenia (SZ) -associated genetic factor. Several genes in the deleted region have been implicated; one of the more promising candidates is DGCR8, which codes for a protein involved in microRNA (miRNA) biogenesis. We carried out miRNA expression profiling (miRNA-seq) on neurons generated from iPSCs derived from controls and SZ patients with 22q11.2 del.
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| |
|
| Overall design |
miRNA profiling of 7 SZ samples and 9 Control samples derived from iPSCs
|
| |
|
| Contributor(s) |
Lin M, Lachman H |
| Citation(s) |
26173148 |
| |
| Submission date |
Jan 28, 2015 |
| Last update date |
Nov 06, 2019 |
| Contact name |
mingyan lin |
| E-mail(s) |
mingyan.lin@phd.einstein.yu.edu
|
| Organization name |
aecom
|
| Street address |
1925 morris park ave
|
| City |
ny |
| ZIP/Postal code |
10461 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
|
| Samples (16)
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|
| Relations |
| BioProject |
PRJNA273806 |
| SRA |
SRP052902 |
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