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| Status |
Public on May 06, 2015 |
| Title |
Transcriptional correlates of FOXP3 expression in suppressive and non-suppressive primary human Treg cell clones. |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Analysis of the transcriptional correlates of FOXP3 expression in suppressive and non-suppressive primary human Treg cell clones. Individual CD4+CD25High or Cd4+CD25- T cells were isolated from human PBMCs and expanded in vitro. After 3 weeks of expansion, individual clones were analysed for FOXP3 expression and in vitro suppressive activity against freshly sorted allogeneic effector T cells. This study analyses the total RNA isolated from FOXP3+ clones with suppressive potency to their non-suppressive counterparts. The resutls of this study should provide insights into the molecular pathways linking FOXP3 expression to distinct aspects of Treg phenotype and function.
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| |
|
| Overall design |
Total RNA obtained from individual clones of primary human regulatory and effector CD4+T cells.
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| |
|
| Contributor(s) |
d'Hennezel E, Bin Dhuban K, Larsson O, Piccirillo C |
| Citation(s) |
25762785 |
| |
| Submission date |
Feb 04, 2015 |
| Last update date |
Jan 28, 2016 |
| Contact name |
Eva d'Hennezel |
| Organization name |
McGill University
|
| Department |
Microbiology and Immunology
|
| Street address |
1650 Cedar avenue
|
| City |
Montreal |
| State/province |
Quebec |
| ZIP/Postal code |
H3G 1A4 |
| Country |
Canada |
| |
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| Platforms (1) |
| GPL10904 |
Illumina HumanHT-12 V4.0 expression beadchip (gene symbol) |
|
| Samples (22)
|
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| Relations |
| BioProject |
PRJNA274579 |
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